Ma, Y. Y., Song, J. Q., Wu, T. F., Liu, Y. P., Xiao, J. X., Jiang, Y. W., and Yang, Y. L. [Leucodystrophy induced by late onset 3-hydroxy-3-methylglutaric aciduria]. View abstract. View abstract. 2007;52(6):1775-1776. Corsi, C., Pollastri, M., Marrapodi, E., Leanza, D., Giordano, S., and D'Iddio, S. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. 3. 2007;21(1):259-264. Res Pharm Sci. Sports Med 1996;22:109-32. 2010;106(4):296-301. 2010;44(7-8):1287-1293. View abstract. Huidekoper, H. H., Schneider, J., Westphal, T., Vaz, F. M., Duran, M., and Wijburg, F. A. View abstract. Your metabolism determines how many calories you burn each day. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Pourmand G, Movahedin M, Dehghani S, Mehrsai A, Ahmadi A, Pourhosein M, Hoseini M, Ziloochi M, Heidari F, Beladi L, Noori M. Does L-carnitine therapy add any extra benefit to standard inguinal varicocelectomy in terms of deoxyribonucleic acid damage or sperm quality factor indices: a randomized study. Tarantini, G., Scrutinio, D., Bruzzi, P., Boni, L., Rizzon, P., and Iliceto, S. Metabolic treatment with L-carnitine in acute anterior ST segment elevation myocardial infarction. 2010;7:16. Anti-ischaemic efficacy of L-propionylcarnitine - a promising novel metabolic approach to ischaemia? Lacour, B., Di Giulio, S., Chanard, J., Ciancioni, C., Haguet, M., Lebkiri, B., Basile, C., Drueke, T., Assan, R., and Funck-Brentano, J. L. Carnitine improves lipid anomalies in haemodialysis patients. Effect of L-carnitine supplementation on acute valproate intoxication. L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms. These 11 healthy foods can help you burn fat. 2005;28(2):141-152. [Values of tandem mass spectrometry in etiologic diagnosis of cerebral developmental retardation]. WebMD does not provide medical advice, diagnosis or treatment. Passeri M, Cucinotta D, Bonati PA, et al. Bazzato, G., Mezzina, C., Ciman, M., and Guarnieri, G. Myasthenia-like syndrome associated with carnitine in patients on long- term haemodialysis. 2006;132(2):121-128. Pharmacol Res. Thal LJ, Calvani M, Amato A, et al. Cureus. L-carnitine might increase the effects of acenocoumarol and increase the chance of bruising and bleeding. Elmslie, J. L., Porter, R. J., Joyce, P. R., Hunt, P. J., and Mann, J. I. Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. Kitano Y, Hashimoto S, Matsumoto H, et al. Lipids Health Dis. Hoffman, J. R., Ratamess, N. A., Gonzalez, A., Beller, N. A., Hoffman, M. W., Olson, M., Purpura, M., and Jager, R. The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Randomized phase III clinical trial of five different arms of treatment in 322 patients with cancer cachexia. Neuromuscul.Disord. View abstract. Anemia and carnitine supplementation in hemodialyzed patients. Bloomer, R. J., Tschume, L. C., and Smith, W. A. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Mezzina C, De Grandis D, Calvani M, et al. Am.J Gastroenterol. Eur J Urol 1996;30(Suppl 2):954. View abstract. 1995;146(12):769-774. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. 2007;18(8):533-540. Wadman, R. I., Bosboom, W. M., van der Pol, W. L., van den Berg, L. H., Wokke, J. H., Iannaccone, S. T., and Vrancken, A. F. Drug treatment for spinal muscular atrophy types II and III. Taking your CoQ10 with food not only helps . 2002;2(3):240-243. Acta Diabetol. Acta Chir Scand Suppl 1983;517:157-164. Faria, C. C., Mota, J. F., Paula Ravagnani, F. C., and Burini, R. C. [The supplementation of L-carnitine does not promote alterations in the resting metabolic rate and in the use of energetic substrates in physically active individuals]. View abstract. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. Cifone MG, Alesse E, Di Marzio L, et al. Drugs Exp Clin Res 1987;13:417-23. What Causes Insomnia? | Sleep Foundation Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Taking too much (2 to 3 grams . Mantovani G, Maccio A, Madeddu C, et al. Drugs R D 2002;3:223-31. 1. J.Nutr.Health Aging 2010;14(3):224-230. Beneficial effects of L-carnitine in myoblastic C2C12 cells. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. J Child Neurol 1991;6:7-14. Urology 2004;63:641-6. View abstract. View abstract. Wei G, Zhou Z, Cui Y, et al. Some dosage forms listed on this page may not apply to the brand name L-Carnitine. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Gunal, A. I., Celiker, H., Donder, E., and Gunal, S. Y. Endocr J. Fertil.Steril. A few more health benefits have been linked to L-carnitine supplements. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Clin Nutr. A., and Barrington, K. J. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Along with its needed effects, levocarnitine (the active ingredient contained in L-Carnitine) may cause some unwanted effects. J Gastroenterol Hepatol 2019;34(12):2062-70. doi: 10.1111/jgh.14765. Porter, N. S., Jason, L. A., Boulton, A., Bothne, N., and Coleman, B. Information from this source is evidence-based and objective, and without commercial influence. While it may aid in weight loss for obese individuals or older adults, a thorough diet and exercise regimen must be in place first. The effect of combined L-carnitine and erythropoietin administration on the anaemia and on the lipid profile of patients on hemodialysis [abstract]. View abstract. L-Carnitine & Hypothyroidism | Healthfully (56-58) L-carnitine levels may be decreased in hypothyroidism, potentially due to reduced synthesis of L-carnitine while we are in a . Kidney Int 1990;38:912-8. Postgrad Med J 1996;72:45-50. J Endocrinol.Invest 2011;34(4):287-291. View abstract. J Child Neurol 1995;10:S40-4. 5A5 Steak Lounge. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. Megri K, Trombert JC Zannier A. View abstract. Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. Lipotropic Injections Benefits, Side Effects, Dosage, and Cost - Healthline Neurobiol Aging 1995;16:1-4. J Inherit.Metab Dis 2006;29(5):631-636. Zhonghua Nei Ke.Za Zhi. View abstract. View abstract. Brass, E. P., Adler, S., Sietsema, K. E., Hiatt, W. R., Orlando, A. M., and Amato, A. Jpn J Clin Pharmacol Ther 1989;20(3):607-618. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Neurochem.Res. Clin Genet. View abstract. View abstract. L-carnitine: Uses, Side Effects, Dose, Health - eMedicineHealth Sci Rep. 2016;6:19188. Sabry, A. View abstract. Madsen KL, Preisler N, Orngreen MC, Andersen SP, Olesen JH, Lund AM, Vissing J. Ren Fail. Nagai, N., Kameda, N., Kobashi, R., Nishida, M., Horikawa, C., Egawa, K., Yoshimura, M., Kitagawa, Y., Abe, K., Kiso, Y., Sakane, N., Kotani, K., and Moritani, T. Effect of L-carnitine intake upon reduction of hunger feeling in young healthy females. Note: This document contains side effect information about levocarnitine. In a person with an overactive thyroid gland, who produces such large quantities of these thyroid hormones that he/she develops a variety of symptoms (including palpitations, increased body temperature, shakiness, irritability, insomnia and weight loss), the inhibiting effects of L-carnitine can be useful (Benvenga, 2005). View abstract. Lancet 1989;2:469-73. Nephron 1991;57(3):306-313. J Clin Endocrinol Metab. If you do not have a dose-measuring device, ask your pharmacist for one. Crill, C. M., Christensen, M. L., Storm, M. C., and Helms, R. A. 4-5-2008;130(12):441-445. The evidence is mixed when it comes to L-carnitines effects on sports performance. Iliceto S, Scrutinio D, Bruzzi P, et al. Low Blood Pressure. Background and aim: Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. Brain Dev. L-carnitine has most often been used by adults in doses of 2 grams by mouth daily. Bianchi, G., Vitali, G., Caraceni, A., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., and Gianni, L. Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-l-carnitine. Garzya G, Corallo D, Fiore A, et al. Clinical Trials Journal 1986;23(6):338-344. People with depression have low blood levels of a substance called acetyl-L-carnitine, according to a Stanford University School of Medicine scientist and her collaborators in a multicenter study. View abstract. Hum Reprod Update 1996;2:87-102. Ann N Y Acad Sci 2004;1033:30-41. Carnitor (levocarnitine) package insert. Br J Cancer 2002;86:1854-7. But doses of less than 3 grams a day seem safe for pretty much anyone. Evangelista, M., Koverech, A., Messano, M., and Pescosolido, N. Comparison of three lubricant eye drop solutions in dry eye patients. Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis. Dealberto, M. J. Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting. Int J Clin Pharm Res 1982;2(2):143-148. A., Gupta, A., Vajifdar, B. U., and Lokhandwala, Y. Y. L-carnitine moderately improves the exercise tolerance in chronic stable angina. View abstract. Physiologie. Rev.Salud Publica (Bogota.) L-carnitine can absolutely cause heart disease - but only if you have the gut microbes needed to break it down, he said. Liammongkolkul, S., Kuptanon, C., Wasant, P., Vatanavicharn, N., Sawangareetrakul, P., Keeratichamroen, S., Cairns, J. R. K., Srisomsap, C., and Svasti, J. To make sure L-Carnitine is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis); if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests. DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., and O'Keefe, J. H. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Smith, W. A., Fry, A. C., Tschume, L. C., and Bloomer, R. J. 7 Best Creatine Supplements for Women in 2023: A Dietitians Picks. View abstract. JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. See our dietitian's picks for women. Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), L-carnitine deficiency. J Am Acad.Dermatol. View abstract. In: Pagon, R. A., Bird, T. D., Dolan, C. R., Stephens, K., and Adam, M. P. GeneReviews [Internet]. Xue, Y. View abstract. View abstract. BMC Comp Altern Med 2002;2:5. View abstract. Mingrone G. Carnitine in type 2 diabetes. Nutrition 2009;25(11-12):1193-1201. View abstract. View abstract. View abstract. Changes in lipid pattern. View abstract. Korean J Gastroenterol. LevOCARNitine (levOCARNitine)." J Eur Acad Dermatol Venereol. Diabetologia 1997;40(1):A32. View abstract. View abstract. 2012;2:CD006659. View abstract. I was under the impression that ALCAR may cause insomnia but not other forms of carnitine. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. L-carnitine and your thyroid | Health24 - news24.com Some research suggests that L-carnitine may help prevent or reduce symptoms of an overactive thyroid, such as insomnia, nervousness, heart palpitations, and tremors. Davini P, Bigalli A, Lamanna F, Boem A. Various lifestyle modifications, and possibly listening to music before bed, might also help. l-Carnitine causes insomnia : r/Supplements - reddit View abstract. A randomized clinical trial. L-Carnitine: Jim Stoppani Explains The Benefits of Carnitine View abstract. View abstract. Cai, T., Wagenlehner, F. M., Mazzoli, S., Meacci, F., Mondaini, N., Nesi, G., Tiscione, D., Malossini, G., and Bartoletti, R. Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. J Child Neurol 1998;13:546-9. Am J Mens Health 2021;15(2):15579883211011371. 2000;54(6):470-477. The highest concentrations are in high energy demand areas such as your brain, heart and muscles. Oncologist. Int J Tissue React. It also caused me to urinate a lot. 2010;5(8):e12140. View abstract. 2006;115(1-2):91-96. 2010;20(11):693-700. 1999;12(1):38-40. Shortland, G. J., Walter, J. H., Stroud, C., Fleming, P. J., Speidel, B. D., and Marlow, N. Randomised controlled trial of L-carnitine as a nutritional supplement in preterm infants. 2007;26(12):967-969. De Pasquale, B., Righetti, G., and Menotti, A. View abstract. View abstract. View abstract. McMackin, C. J., Widlansky, M. E., Hamburg, N. M., Huang, A. L., Weller, S., Holbrook, M., Gokce, N., Hagen, T. M., Keaney, J. F., Jr., and Vita, J. Effects of wuzi yanzong liquids combing with L-carnitine on oligospermia and asthenospermia. Toxicol Res (Camb). View abstract. Indian Pediatr 1992;29:1501-5. J Am Coll Nutr. AIDS 2004;18:1549-60. Vacha, G. M., Giorcelli, G., D'Iddio, S., Valentini, G., Bagiella, E., Procopio, A., di Donato, S., Ashbrook, D., and Corsi, M. L-carnitine addition to dialysis fluid. Vance CK, Vance H, Winter SC, et al. J Eur Acad Dermatol Venereol 1999;13:205-9. The Therapeutic Effects of Acetyl-L-Carnitine on Peripheral Neuropathy 2018 Jun;20(3):285-290. Ann.Clin Psychiatry 2009;21(4):213-236. Boehm G, Stahl B. Oligosaccharides from milk. Version: 1.03. ALCAR might do the same, but studies haven't confirmed this [95, 96, 97]. Serati AR, Motamedi MR, Emami S, et al. An JH, Kim YJ, Kim KJ, et al. Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Healthline Media does not provide medical advice, diagnosis, or treatment. View abstract. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. In addition to the L-carnitine produced in your body, you can also obtain small amounts by eating animal products like meat or fish (5). The role of carnitine supplementation during valproic acid therapy. J Am Coll Cardiol 1999;34:1618-24. Whats more, five of the participants taking L-carnitine experienced nausea or diarrhea (24). Pollard, L. M., Williams, N. R., Espinoza, L., Wood, T. C., Spector, E. B., Schroer, R. J., and Holden, K. R. Diagnosis, treatment, and long-term outcomes of late-onset (type III) multiple acyl-CoA dehydrogenase deficiency. Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers. It can cause side effects such as stomach upset, heartburn, diarrhea, and seizures. Corbucci, G. G., Melis, A., Piga, M., Marchionni, A., and Calvani, M. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia. Academic J.Shanghai Second Med.Univ. Anon. View abstract. "L-carnitine and platelet aggregation in uremic patients subjected to hemodialysis." 2009;79(3):131-141. Zeitschrift fr Orthomolekulare Medizin 2009;7(3):22-24. View abstract. 2014 Jul 21;14:88. 2006;44(3):525-530. Use of D,L- and L-carnitine in uraemic patients on intermittent haemodialysis. Eur Heart J 1992;13:251-5. According to the University of Maryland Medical Center, carnitine is successful in treating hyperthyroidism possibly because of its ability to block the effects of thyroid hormones - a potentially dangerous effect for people suffering from an underactive thyroid. View abstract. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Merchant, R., Jain, A., Udani, A., Puri, V., and Kotian, M. L-carnitine in beta thalassemia.